Randomized, prospective dose-comparability study of amlodipine or nifedipine gits in hypertension

Nifedipine GITS Package Insert

A comparative crossover evaluation of amlodipine and nifedipine GITS before and after a missed dose: 48-h blood pressure profiles.

Despite good pharmacologic control of blood pressure (BP), the untoward effects of noncompliance and missed doses have become a matter of concern, evidenced by the high frequency of deviations from prescribed treatment. Missing one or more days of medication on these “drug holidays” can disrupt the steady level of the drug and lead to rebound reactions when the dose is suddenly stopped, and res...

Effectiveness of combination therapy with nifedipine GITS: a prospective, 12-week observational study (AdADOSE)

BACKGROUND Observational studies can provide important information on the efficacy and safety of antihypertensive agents in the real-life clinical setting. AdADOSE was a large observational study to assess the effectiveness of nifedipine GITS in combination with other antihypertensive agent(s). The study was also the first to examine the role of combination therapy with nifedipine GITS in the M...

Combination therapy with nifedipine GITS 60 mg: subanalysis of a prospective, 12-week observational study (AdADOSE)

BACKGROUND AdADOSE was a 12-week, international, observational study conducted in the Middle East and Russia where patients received nifedipine gastrointestinal therapeutic system (GITS) at a daily dose of 30, 60, or 90 mg as part of an antihypertensive combination therapy. This subgroup analysis of the AdADOSE study assesses the efficacy and tolerability of nifedipine GITS combination therapy ...

Differential effects of lercanidipine and nifedipine GITS on plasma norepinephrine in chronic treatment of hypertension.

This study aimed to compare the effects of two long-acting dihydropyridine calcium channel blockers (CCBs) with different pharmacologic properties, lercanidipine and nifedipine Gastro-Intestinal Therapeutic System (GITS), in the chronic treatment of essential hypertension. After a 4-week placebo run-in period, 60 patients of both sexes were randomly treated with lercanidipine 10 to 20 mg or nif...